| 英文品名 |
lorvotuzumab mertansine |
| 名称来源 |
p-INNList-103,2010; ; |
| 化学表述 |
immunoglobulin G1-kappa, anti-[Homo sapiens NCAM1 (neural celladhesion molecule 1, CD56, NCAM-1)], humanized monoclonalantibody conjugated to maytansinoid DM1;gamma1 heavy chain (1-448) [humanized VH (Homo sapiensIGHV3-30*03 (91.80%) -(IGHD)-IGHJ4*01) [8.8.11] (1-118) -Homosapiens IGHG1*01 (119-448)], (221-219')-disulfide with kappa lightchain (1’-219’) [humanized V-KAPPA (Homo sapiens IGKV2-30*02(92.00%) -IGKJ1*01) [11.3.9] (1'-112') -Homo sapiens IGKC*01(113'-219')]; (227-227"":230-230"")-bisdisulfide dimer; conjugated, onan average of 3 to 4 lysyl, to maytansinoid DM1 via a thiopentanoatelinker |
| CA登记号 |
1008106-64-6 |
| 结 构 式 |
|
| 品种类别 |
antineoplastic; |
|
